A neural-symbolic AI agent system for biomedical concept mapping
npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02594-6 A neural-symbolic AI agent system for biomedical concept mapping
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Gemma4 26B A4B runs easily on 16GB Macs
Typically, models in the 26B-class range are difficult to run on 16GB macs because any GPU acceleration requires the accelerated layers to sit entirely within wired memory. It's possible with aggressive quants (2 bits, or maybe a very lightweight IQ3_XXS), but quality degrades significantly by doing so. However, if run entirely on the CPU instead (which is much more feasible with MoE models), it's possible to run really good quants even when the models end up being larger than the entire available system RAM. There is some performance loss from swapping in and out experts, but I find that the performance loss is much less than I would have expected. I was able to easily achieve 6-10 tps with a context window of 8-16K on my M2 Macbook Pro (tested using IQ4_NL and Q5_K_S). Far from fast, but
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